In the mid-19th century, Italy was under the rule of the Austro-Hungarian Empire. In order to liberate his motherland, Angelo (Olivier Martinez), a captain of the light cavalry, conspired to launch a riot to overthrow colonial rule, but had to go into exile in France because the plan was leaked. Because of the betrayal of his childhood friend, Angelo was hunted down by Austrian spies in France. Angelo, who was on the run, accidentally broke into a plague area in France, where people were in mourning and almost crazy. The locals believed that it was Angelo who poisoned him, and Angelo became the target of pursuit for no reason. One day, Angelo accidentally fell from the roof into an attic and met Paulina (Juliette Binoche), a woman who had been separated from her husband. When he learned that Paulina was in a difficult situation, Angelo was determined to help her find her husband. As they traveled through the plague area, Paulina was unfortunately infected with the plague...