The story of "Blue Sky and White Clouds" tells a confusing murder case. Connie (played by Liang Yongting), a middle school student, was born with heart leakage disease and has few friends. She planned to murder her parents, but she knew she was weak, so she decided to drag her classmate Eric (played by Gu Dingxuan) into the water, and the two became accomplices. Connie had no regrets after murdering her parents. The case was taken over by the female detective Angela (played by Tang Laiyan) from the serious crime team. The newlywed Angela lives with her father (played by Huang Shutang) who suffers from Alzheimer's disease and her husband Tony (played by Li Renshen). Angela, who has just become pregnant, seems to have a happy family, but she finds that her emotions are increasingly affected by the case. Slowly, she seems to begin to understand why Connie has embarked on this road of no return...