The cat on the highway comes from a proverb, which is used to describe things that are destined not to last long. Giovanni (Antonio Albanese) is a typical intellectual who reads books and newspapers every day and thinks about life seriously. He always believes that people can have real trust and integrate with each other. Monica (Paola Cortellesi) is the opposite of Giovanni. As a supermarket cashier, she has to deal with guests of different skin colors and races every day. She often feels overwhelmed and very pessimistic about communication between people. God played a little joke. These two people who can't get along with each other, their children were tied together by the red line. The two who learned about this relationship sincerely hope that it can end as soon as possible like the cat on the highway.