In the first season, Dr. Bill Masters (Michael Sheen) successfully expanded human sexuality into his research field, but he also struggled to find a balance and distinction between his professionalism and personal dedication to his work, and he developed an emotional entanglement with his research assistant Virginia Johnson (Lizzy Caplan). With the arrival of the second season, the situation becomes more complicated. As the relationship between the two continues to develop, Bill's already strained marriage reaches a critical climax, his career and personal career are in danger, and the conflict between love and work becomes the biggest contradiction Bill encounters in the new season.