Guitarist El (Antonio Banderas) is the most feared sharpshooter in the Mexican desert. He has destroyed local drug lords and gangs one after another, and therefore has made enemies everywhere. After the loss of his beloved wife, the disheartened El began to wander around with his guitar on his back, and has since disappeared. Nowadays, the drug lord Barori (Willem Dafoe) has gradually established his drug kingdom. He is ambitious and is even plotting to assassinate the president and overthrow the Mexican regime. CIA agent Sanders (Johnny Depp) learned of Barori's conspiracy, so he found El. The former iron-blooded warrior El certainly would not stand idly by, and he finally returned to the arena. However, things are not as simple as they seem. A legend is slowly unfolding in the Mexican desert.