Amy (Amy Schumer) was taught by her father that marriage and monogamy are unrealistic. When she grew up, she was keen on clubbing and dating different men but never fell in love. One day, as an editor of a men's magazine, she went to interview Aaron (Bill Hader), a doctor who specializes in treating sports injuries for athletes. Unexpectedly, she met the man who might end her perfect single life. This film was written by the heroine Amy Schumer and adapted from her own real experience.