On August 29, 2005, the powerful typhoon Katrina was about to hit New Orleans. In a local hospital, the man Nolan Hayes (Paul Walker) ushered in the sad and happy moments of his life. He just welcomed his newborn baby daughter, but his beautiful wife Abigail (Genesis Rodriguez) passed away after giving birth. The delicate baby is unable to adapt to the new environment and can only be placed in an incubator to rely on machines to survive. Facing the completely unfamiliar little life in front of him, Nolan and his wife's beautiful memories emerged one after another, making this man who has experienced major joys and sorrows feel mixed. The storm is getting stronger, the hospital is short of staff, and doctors and patients are forced to evacuate urgently, and the collapsed dam pushes the disaster to its peak. The lonely Nolan must race against time and fate to protect his last relatives in this world with his own strength...