The film revolves around the work of spy novelist Yellie Conway (Bryce Dallas Howard). Yellie's novels tell the story of mysterious agent Argyle (Henry Cavill) and his mission to dismantle a global spy ring, but the plot of the novel unexpectedly begins to coincide with the covert operations of real spy organizations. Accompanied by agent Aiden (Sam Rockwell), Yellie and his cat Alfie (Chip) travel the world, trying to defuse crises before the spy organization's killers act. At this time, the line between the fictional world of the novel and reality begins to blur. What follows is an adventure that spans the globe.