In the first half of the 19th century, Abraham Lincoln (Benjamin Walker), who later left an important footprint in American history, was just a young man carrying the hatred of killing his mother. On a night full of ominous atmosphere, he raised his gun and stabbed his enemy, but the enemy who had suffered a fatal wound counterattacked fiercely. At a critical moment, Lincoln was rescued by a man named Henry Sturgess (Dominic Cooper). He learned from Henry that he was almost killed by his enemy who turned into a vampire. After some hard training, Lincoln became a vampire hunter. At this time, vampires have spread throughout the southern United States and gradually advanced to the north. Under Henry's instructions, Lincoln returned to town and launched a seemingly endless hunt for vampires, and the vampire maker Jack Baz (Marton Csokas) also noticed the existence of this "life-claiming death god"...