The story takes place in the late Qing Dynasty, when the Huaihe River was ravaged by the plague. Uncle Long and his sworn brother Fang Xiucai went to the epidemic area for treatment, but found that the plague was a man-made disaster. The murderer was Long Erye (played by Li Zixiong) who had committed adultery with his grandmother (played by Chen Shali). Erye did not care about the brotherhood, and joined hands with his grandmother to kill his brother, and then framed Fang Xiucai. Mrs. Fang mistakenly held Long Er's illegitimate son on the way to escape. A few years later, the descendants of the Long family were adopted by the Guan family and named Houpu (played by Zhong Hanliang). He grew up in the Guan family who practiced medicine and learned to be compassionate since childhood. The son of the Fang family, Wu Sheng (played by Liu Kaiwei), was spoiled and became a young master. They both fell in love with Jingxin (played by Lu Yi), and Jingxin was more devoted to Houpu. Liansheng (played by Yang Rui) of the Long family also did not marry Houpu, but she did not know that Houpu was her biological brother. At this time, Fang Xiucai's wife came back, and she wanted to get back the wronged souls who died that year...