In the 1990s, a remote and backward mountain village in China. Driven by profit, villagers sold blood to make money, but they were also infected with the terminal disease of the century, AIDS, and their lives were counted in seconds. Zhao Qiquan (Pu Cunxi), the eldest son of Lao Zhuzhu (Tao Zeru), lost his conscience. As a "bloodhead", he became the first person in the village to get rich, and he did not repent for sacrificing villagers and even his family. The guilty Lao Zhuzhu concentrated the villagers who were infected and discriminated against in an abandoned primary school for unified care. His second son Zhao Deyi (Aaron Kwok) also went with him. On the island of death where no one pities, the patients were still fighting against each other under the drive of greed in their hearts at the last moment of their lives, which made people see no hope at all. During this period, Deyi and his cousin Xiaohai (Cai Guoqing)'s daughter-in-law Qinqin (Zhang Ziyi) sympathized with each other and fell in love with each other. The two people who had already suffered discrimination became evil people who betrayed the whole world. As their lives passed by little by little, they still ran with all their strength, chasing the small and fleeting sad happiness...