By chance, Smurfette (voiced by Demi Lovato) found a lost map that led to a mysterious village. In order to verify the authenticity of the village, Smurfette and her friends Smart (voiced by Danny Pudi), Jianjian (voiced by Joe Manganiello), and Clumsy (voiced by Jack McBrayer) embarked on a journey together. Along the way, the fledgling foursome encountered countless dangers, but they were always able to turn danger into safety with their wisdom and luck, and the friendship of the four was also put to the test. The evil Gargamel (voiced by Rainn Wilson) also knew the existence of the village. In order to be the first to reach the village, Gargamel began to do everything possible to obstruct the future of Smurfette and his group.