The story tells the story of a man nicknamed "Biology Uncle", Yukio Mitsuhashi (Yasuzo Harada), and his daughter, who quarreled and reconciled because of a heated incident. Yukio Mitsuhashi is a single father who works as a public relations officer for a sanitary products company. He has a high school daughter and a junior high school son. Six months ago, he became popular because of a video that called on everyone to understand women's physiology, and was called "Biology Uncle". But one day, he got into a fight with the commentator Kitajiro Urara (Rinko Kikuchi) on a live information variety show, and accidentally said "I even know my daughter's menstrual period clearly", which caused a heated argument. As a result, even his daughter, Hana Mitsuhashi (Juri Uesaka), couldn't stand the rumors at school and ran away from home. Can he and his daughter explain the differences in their ideas about physiology and make up?