For the young man John (Oliver Hudson), there seems to be a real good thing in the world. By chance, he inherited his uncle's house on a small island. To celebrate this moment, John invited his brother Matt (Eric Lively) and their girlfriends, good friends Nikki (Michelle Rodriguez), Sarah (Taryn Manning), and Noah (Hill Harper). They only indulged in the exotic customs of the island, but ignored the dangers hidden behind it. Soon, Sarah was attacked by a mad dog, and panic quickly spread among them. It turned out that there was a dog training center on the island. The island was deserted, but the dogs infected with rabies survived. On this isolated island, these young people became the target of vicious dogs hunting...