The protagonist Dylan (Michiel Huisman), who has a strict work and rest schedule, has a natural ability to see through the rules. At 2:22 p.m. one day, Dylan Branson, an air traffic controller, was paralyzed by a mysterious light, which almost caused the plane he was commanding to crash. From then on, he would feel this light every day, and gradually found himself in a certain cycle. By chance, Dylan met Sarah (Teresa Palmer), who made him fall in love at first sight. The two chatted and were surprised to find that Sarah was the passenger on the flight that almost caused the flight accident. It was a coincidence that they were born on the same day of the same month of the same year. As the two got to know each other better, Dylan and Sarah had more and more coincidences. Frequent hallucinations and constantly cyclical events linked their fate to a murder case that occurred at New York Central Station thirty years ago. Dylan has been exploring the secrets behind "2:22" and found that the murder case thirty years ago is about to be repeated.