On New Year's Eve, a girl who had taken an overdose of sleeping pills suddenly rushed into the emergency room. During the treatment, Du Mei met Fang Yan and his buddy Pan Youjun by accident. Du Mei's friend Jia Ling is a flight attendant who works in the same airline as Fang Yan. So, these four single men and women became friends. Jia Ling, who had just broken up with her boyfriend, hit it off with Fang Yan at first sight. The two of them were dealing with emotional games in a vague way, but soon Jia Ling discovered that Du Mei also had a special feeling for Fang Yan. Gradually, the relationship between the three became subtle, and an inexplicable emotional undercurrent emerged. On New Year's Eve, Fang Yan had a strong love for the lonely and helpless Du Mei for the first time. In the end, Jia Ling chose to withdraw, and Fang Yan and Du Mei came together. After experiencing a sweet love, the two got married with everyone's blessings and had a home of their own. In their life together after marriage, Du Mei and Fang Yan slowly discovered that they had different perceptions of love. Faced with Du Mei's reckless devotion to love, Fang Yan was at a loss. He increasingly found that he could not bear the emotional burden and could only choose to escape. At first, the two would try to make up after every quarrel, but gradually, such a life made them more and more numb and indifferent. In the face of the cruel reality, Du Mei could not face it and could only desperately maintain it. She began to suspect Fang Yan, which happened to hurt herself and Fang Yan. Finally, after a big quarrel, Du Mei tied Fang Yan at home and forced Fang Yan to say "I love you" to her with a knife. Fang Yan could not bear it and had to break the window. The two chose to divorce in complete disappointment. On the day of the divorce, the two were like strangers and went their separate ways, and have not contacted each other since then. After the divorce, Fang Yan resigned and left Beijing with Pan Youjun to do business in Chengdu, while Du Mei found out that she was pregnant. Just when she decided to keep the child, she miscarried due to an accident. Soon, the painful Du Mei had a medical accident and was expelled from the hospital. In despair, Du Mei chose to leave without saying goodbye. A year later, Fang Yan returned to Beijing. At this time, he learned about Du Mei's true situation from Jia Ling. With deep guilt, Fang Yan found Du Mei with great difficulty and took her to his home. After that, the two lived under the same roof again as friends. At this time, Qian Kang, a high school classmate who had pursued Du Mei, and Han Liting, a girl Fang Yan met in Chengdu, each launched an emotional offensive against them. In the complex emotional relationship, Du Mei and Fang Yan found that they could not forget each other more and more. The two still loved each other deeply and were deeply attached to each other. In the end, their emotions also moved Qian Kang and Han Liting, and they took the initiative to hope that Du Mei and Fang Yan would reunite. Just when Du Mei and Fang Yan were reflecting on their marriage, their feelings and decided to start over, Fang Yan found that he was suffering from a strange disease. He secretly went to the hospital for a check-up. The doctor told Fang Yan that his disease was called "myasthenia gravis" and there was currently no particularly good cure. Fang Yan, who couldn't bear to drag down Du Mei, had no choice but to find Jia Ling, hoping that she could help him. In the conflict, Jia Ling agreed to his request because of Fang Yan's love for Du Mei. The two painfully performed a scene of love affair in front of Du Mei. Faced with this scene, Du Mei was deeply shocked and left alone, and the two parted ways again. Fangyan, who had concealed his illness from everyone, left quietly. Soon, Du Mei learned the truth from Jia Ling. She desperately looked for Fangyan and finally found Fangyan, whose condition had worsened, at the beach where they had agreed when they were in love. At this moment, Fangyan was in despair. Seeing himself weakening day by day, he chose to commit suicide, but was stopped by Du Mei. She told Fangyan not to give up anyway. Finally, inspired by the power of Du Mei's love, Fangyan decided to fight the disease. The two returned to Beijing and attended the wedding of Qian Kang and Han Liting. They embraced each other in front of the newlyweds and listened to the sacred wedding vows. At this moment, the two were filled with mixed feelings and stared at each other for a long time. They smiled at each other. Du Mei and Fangyan boarded the flight to Shenzhen together. In order to fight the disease, they made their last efforts side by side. The plane roared through the clouds, and the dazzling sun was just ahead...