Former CIA agent Frank Moses (Bruce Willis) retired and stayed away from the battlefield, enjoying the leisurely days with Sarah (Mary-Louise Parker). One day, he witnessed the tragic death of his old partner Marvin Boggs (John Malkovich) without warning, and he became the next target to be hunted down. Everything originated from the Nightshade Light Project during the Cold War. In order to prevent the plan from spreading on the Internet, the US government was eager to eliminate the insiders Frank and Marvin. Marvin came back to life and rescued the trapped Frank. The two fled with Sarah, looking for the key figures of Nightshade Light. At the same time, Victoria (Helen Mirren) was ordered by the British MI6 to hunt down Frank and others, and Han Chaopei (Lee Byung-hun), the world's top killer who had crossed paths with Frank, was also hired by the US government to follow. The long-lost fight starts again... This film is based on the comics by Warren Ellis and Cully Hamner.