This film is adapted from the novel of the same name by the best-selling American author Dan Brown. Victoria Vitale (Ayelet Zurer), a scientist at the European Organization for Nuclear Research, and her father collected antimatter in a high-speed particle collider experiment, but found that her father was killed and the "Illuminati" symbol was branded on the chest of the corpse. The highly explosive antimatter was stolen and appeared in the Vatican in Rome, where a new pope was being elected, threatening the safety of the Catholic Church and the entire Rome. At the same time, the cardinals of the four main candidates for the pope disappeared mysteriously. Under the instruction of the Pope's chamberlain (Ewan McGregor), Professor Robert Langdon, a semiotics expert at Harvard University, and Victoria were invited to the Vatican to assist the Roman police in their search. Langdon persuaded the chief detective of Rome, Olivedi (Pierfrancesco Favino), to start a time war with the "Illuminati" among the famous churches in Rome according to the prompts of "earth, air, fire, and water"...