In the future of 2092, Mars has become a popular holiday destination for people on Earth. Nemo Nobati (Jared Leto), 118 years old, is the last natural person who will still die. With confused memories, he keeps recalling his childhood in hypnosis and interviews, but he has a completely different life at every fork in his life. In these different versions, there is Anna (Diane Kruger), who became Nemo's "sister" after his mother (Natasha Little) and father (Rhys Ifans) divorced and remarried, and Elise (Sarah Polley), who suffers from depression and emotional instability after marriage, and Jean (Linh Dan Pham), an Asian girl with three children. Intertwined in the explanation of the Big Bang theory, superstring theory and the characteristics of time, what is the truth of Nemo's life? The film was nominated for the Golden Lion Award at the 2009 Venice Film Festival, and won the Best Biographical Film Award in the Fiction Category and the Golden Osella Award for Best Technical Contribution.