The charming Captain Jack (Johnny Depp) is back again. This time, he encounters a more powerful enemy - the legendary undead David Jones (Bill Nighy), who drives the terrifying "Flying Dutchman" clipper. No ship can surpass it in speed and equipment. Captain Jack owes Jones a blood debt. He must find a way to break it before the deadline, otherwise he will always bear the blood debt and become Jones' slave for the rest of his life. Of course, Captain Jack's good friend Will Turner (Orlando Bloom) is also involved in his bad luck. Because of Jack, Will and Elizabeth (Keira Knightley)'s wedding was forced to be cancelled, and Elizabeth was imprisoned. In order to save her, Will can only go to find Jack. This time, the two good friends encountered a huge mysterious sea monster, unfriendly island natives, and the gorgeously dressed fortune teller Delma. Will's long-lost father, "Bootstrap" Bill Turner (Stellan Skarsgard), appeared strangely at a critical moment, becoming a turning point in the overall situation...