Peter Parker (Tobey Maguire) is just an ordinary high school student in the United States. When he was bitten by a mutant spider that escaped from the Spider Museum, Peter's life changed completely. He became like a spider, with various spider-specific superpowers: spraying highly sticky spider silk from his fingers, flying over eaves and walls, etc. Peter was extremely excited and began to use his superpowers to make money. But when his favorite uncle was killed by the criminal he let go, Peter vowed to use his superpowers to fight crime. Norman (Willem Dafoe), the father of Peter's friend Harry, is the owner of a biotechnology company. He was distressed because the aircraft produced by his company was not appreciated by the military leaders. Once Norman inhaled nerve gas accidentally and had superpowers, which triggered his evil nature. He rode the aircraft he developed to destroy and kill people everywhere. Peter's Spider-Man began to attack!