Killer Chefer (Jason Statham) was plotted against by someone, and his nemesis, the Richie brothers, injected him with a deadly poison. After Chefer woke up, he was furious and in great pain. In order to find an antidote, he broke into the gang stronghold in Orlando, but found nothing. Desperate Chefer went to Beverly Hills and asked for help from the boss Carretto, but the latter claimed that he was responsible for the Tang Jin incident. Chefer's doctor told him that only by increasing the level of adrenaline in his body could he maintain his life. In order to get revenge, the angry Chefer killed Richie's brother in the Prince Hotel and broke into the hospital to search for related drugs, which attracted a large number of police. Although he became a wanted criminal in the city, Chefer still desperately rescued his girlfriend Eve (Amy Smart). After escaping the hunt, he confessed to his girlfriend that the source of all this was because he had let go of the Hong Kong triad drug tycoon Tang Jin, so his enemies killed him. His girlfriend understood his righteousness, and embarked on the road of revenge with Chefer...