Twenty years ago, an operation caused the breakup of two pediatric interns, Kuang Cong-yan (played by Ma Guoming) and Hui Gan-feng (played by Zheng Jiaying). As time went by, Cong Xin became a consultant pediatric surgeon at the top hospital "Annie Hospital", while Gan Feng, who was dedicated to protecting lives, settled in a second-tier hospital. The two had originally gone their separate ways, but unexpectedly met again because of a liver transplant operation, and their fates were connected from then on. Cong Xin schemed to force Gan Feng to join Anne Hospital, and then found his former comrades-in-arms, cardiothoracic surgeon Zhang Yixin (played by Linda Chung) and surgical director Mak Hoi-kei (played by Zhou Jiayi) to create a perfect team, with the purpose of piecing together the blueprint in his mind to pave the way for the construction of Hong Kong's first "pediatric center". After experiencing the life and death stories of sick children, Cong Xin and Gan Feng, who were originally at odds with each other, gradually untied their knots. At this time, specialist doctor Wen Boxi (played by Luo Ziyi) and specialist intern Lian Zhuoying (played by Zhang Baoer) discovered that the operation 20 years ago involved a major medical error, and the main surgeon was Zhong Huaishuang (played by Gong Ci'en), the dean of the School of Medicine of Dong-A University affiliated to Anne Hospital. They decided to uncover the truth...