The story tells that LeBron and his young son Dom are trapped in the virtual space of the "Warner Bros. Cinematic Universe" by artificial intelligence. In order to return home safely, he must lead Bugs Bunny, Lola Rabbit and those unruly Looney Tunes cartoons to defeat an all-star basketball team. This duel is the biggest challenge in LeBron's life. It will also redefine the relationship between him and his son and let LeBron realize the true meaning of "being himself"; the Looney Tunes friends must break the rules and use their unique skills beyond their normal level to impress LeBron. However, they are facing a group of unprecedented and invincible artificial intelligence-enhanced opponents, the "Doomsday Maniacs". Can LeBron and the Looney Tunes really defeat them?