On the tranquil and beautiful Mekong River, gunfire suddenly broke out. All the crew members of the Chinese merchant ships "Yuanping" and "Xingsheng" disappeared. Not long after, the bodies of 13 Chinese crew members surfaced. This was the "October 5" tragedy in 2011 that shocked the whole country. After that, China quickly took the lead in forming a joint task force. Jiang Haifeng (played by Chen Baoguo), director of the Narcotics Control Bureau of the Ministry of Public Security, served as the team leader. He tried to prove the innocence of the victims to his international counterparts, and at the same time recruited senior criminal police including Gao Ye (played by Wang Qianyuan) to join the task force. Under the police's pursuit, cunning and fierce drug dealers such as Meng Hong (played by Danny Lee), Canlila (played by You Yong), and Mo Xiong (played by Zhang Zhaohui) surfaced one after another, and a deadly battle between black and white is about to begin... This film is adapted from real events.