Doug (Tim Allen) is a bored houseboy who is bored at work and despised by his son; Bobby (Martin Lawrence) quits his job and wants to be a writer, but he makes no progress and is ridiculed by his wife all day; Dudley (William H. Macy) is a software engineer, a standard geek otaku, who doesn't have a girlfriend at his age because he dares not talk to women; Woody (John Travolta) has been a playboy for half his life, but now his company is facing bankruptcy and his supermodel wife is leaving him. Four old friends, with their own midlife crisis, start a Harley motorcycle trip at Woody's suggestion. They wear leather clothes, tie turbans, and dress up as unrefined "easy riders". They start to travel across New Mexico, trying to regain their lost self, long-lost passion and fun in a trip full of situations and reckless consequences, but regret this life...