In a certain year in the near future, a deadly and destructive virus broke out on Earth, causing the death of more than half of the world's population. The boundless ocean seems to be a divine domain that the virus cannot enter, and the Arleigh Burke-class guided-missile destroyer "Nathan James" commanded by Captain Tom Candler (Eric Dane) has become a Noah's Ark drifting aimlessly and waiting for pardon after the punishment of heaven. In order to preserve the manpower and ensure that the two filterable pathogen scholars on the ship develop an antidote to the poison, Captain Candler defied the call of the US Provisional Government and took the crew on a long journey. However, the dangers along the way were doubled. In order to replenish supplies and vaccines, they had to stop at ports and land. In addition, ships from other countries tried to snatch the antidote. What's more terrifying is that despair and panic are also spreading among the crew. When will the journey end without seeing the future... This film is adapted from the novel of the same name.