Legend has it that drinking water from the Holy Grail used by Jesus at the Last Supper can make one immortal. During a gold digging activity, the stele recording the Holy Grail was discovered, and the possibility of the Holy Grail's existence attracted a large number of crazy people to start searching. Dr. Indiana Jones (Harrison Ford) is also one of them, and even his father, Old Jones (Sean Connery), is caught up in it - but he disappeared after leaving Jones with the Holy Grail's notes. Stepping onto the land of Venice, Jones met with Dr. Snyder (Alison Doody) who had made an appointment in advance. After they found the Holy Shield in the library with clues, they began to be hunted down inexplicably by the Cross Sword Brothers. After some twists and turns, Jones finally found Old Jones. At the same time, Snyder's Nazi identity was exposed and the notes were taken away. The Holy Grail could fall into the hands of the Nazis at any time. So, Jones and his son began to work together to stage a wonderful drama to save the Holy Grail!