The story follows last season. Through a well-planned explosion, Walter (Bryan Cranston) finally got rid of the long-standing threat Gustavo (Giancarlo Esposito) and uprooted the drug empire that Gustavo built. However, the success in "career" did not bring too much happiness to Walter, because the relationship between him and his wife Skyler (Anna Gunn) fell to the freezing point again. Gustavo died, but Walter's ambition did not disappear. He joined forces with Jesse (Aaron Paul) and Mike (Jonathan Banks) to start building his new empire. By chance, Hank (Dean Norris) found conclusive evidence in Walter's home that Walter was Heisenberg. Under the huge blow, he was determined to kill his relatives for the sake of justice. His former brother-in-law has now become an opponent. At the same time, a new force is gaining strength in the drug world. They are about to become Hank's most powerful enemy.