Veteran agent Ethan Hunt (Tom Cruise) also has a moment of carelessness. When he received the latest mission, he was plotted by the mysterious organization "Syndicate" and fell into the hands of the other party. The Syndicate is a secret organization composed of former agents from all over the world, which has been regarded as groundless by the CIA. With the help of the other member Isa Foster (Rebecca Ferguson), Ethan escaped and promptly reported the exact existence of the Syndicate to William Brad (Jeremy Renner). However, Brad's life was not easy at this time. The IMF agency he was in charge of was accused and ordered to disband by the CIA due to incidents such as Russian nuclear warheads. When he learned that the organization was plotting to assassinate the Austrian president, Ethan contacted his old partner Benji Dunn (Simon Pegg) to take action and met the mysterious girl Isa again. In the following series of events, the true face of the Syndicate is gradually revealed, and their true purpose is finally revealed...