The drama is adapted from the work experience of the well-known forensic doctor Wang Xuemei. It tells the story of an unconventional special case team composed of picky team leader Shang Jie, focused and professional female forensic doctor Xia Ying, all-round trace appraiser Li Xuekai, innocent information analyst Song Mi, and rich second-generation psychological profiler Ying Ming. It brings together all kinds of "unreliable" people in the bureau. Through concerted efforts, they have successively solved various bizarre homicides, and caught a serial killer who had fled to three or four cities and used accidental killing as a means of killing. They became famous in one battle. The special case team then successively solved the Nanshan Park dismemberment case, the bizarre family massacre, and captured brother killers with a strong sense of anti-detection.