Mike (Wentworth Miller) and his brother Lincoln (Dominic Purcell) have been dependent on each other since their mother died and their father disappeared. Although Lincoln is a street gangster, he borrowed $90,000 from a loan shark without telling his brother so that he could successfully complete his studies and make a name for himself. He lied to Mike that it was his mother's insurance. With the money, Mike successfully became a structural engineer and entered the upper class. In order to repay the loan shark, Lincoln reluctantly agreed to the request of a strange man to shoot someone. When Lincoln arrived at the parking lot as planned, he found that his target had been shot and died. In a panic, Lincoln ran back home. The police quickly caught him at Lincoln's home. The innocent Lincoln then found that all the evidence pointed to himself. Mike finally learned from his friends what his brother had done for him. He regretted his arrogance towards his brother at the time. After investigation, Mike believed that his brother was framed, and the frame-up might involve a senior government official behind the scenes! Seeing that all methods could not help his brother clear his name, Mike remembered that he had taken over the renovation project of Fox River Prison where Lincoln was imprisoned. He had a complete set of blueprints there. So, after a year of careful preparation, Mike deliberately committed a crime and entered Fox River Prison. He wanted to use his own strength to successfully rescue Lincoln who was sentenced to death...