Leonard and Sheldon are roommates. Their mutual friends Howard and Rajesh are genius scientists working at the same university. They are all geeks—superior IQ but low EQ; they love video games and comics, and are not good at communicating with people, let alone getting along with the opposite sex; they use science to solve everything, which has caused a lot of jokes. The appearance of their beautiful neighbor Penny has brought a new change to their lives. The collision between the otaku scientist and the beautiful waitress has a wonderful chemical reaction. Leonard, who has been secretly in love with Penny for a long time, finally got the opportunity to date her. Howard, Raj and Sheldon helped him scientifically analyze the dating results. With the precise calculations of scientists, can Leonard win the beauty?