The wheel of history rolled over countless lives and finally entered the Ming Dynasty. However, the jar-like etiquette did not move towards civilization with the progress of history, but instead more strictly imprisoned the freedom of human nature. Especially women, they were not only physically bound, but also deeply suppressed their souls. The beautiful girl Tan Yunxian (played by Liu Shishi) served the emperor as a doctor for generations, but suffered a catastrophe due to the frame-up of a traitor. After suffering, the Tan family passed down the family motto of "never practicing medicine". But Yunxian was talented and loved medicine. With the tacit consent of her grandmother, she was able to concentrate on studying medicine. During this period, she accidentally met the dandy brother Yuanbao, but she didn't know that this person was the current emperor Ming Yingzong Zhu Qizhen (played by Huo Jianhua). After several turns, Yunxian entered the inner court of the palace, and thus embarked on a dangerous and challenging medical career. Looking back, there is no way back. This legendary female doctor is destined to write a heavy stroke in history... This film is based on real historical figures.