Since the fateful encounter with three lovely girls, Margo (Miranda Cosgrove), Edith (Dana Gaier) and Agnes (Elsie Fisher), Gru (Steve Carell) has completely cleaned up his villainy and is now a amiable father and a businessman who makes pudding jelly with a bad taste. Of course, nothing is perfect. During this period, his old partner Dr. Nafario (Russell Brand Russell Brand), who longed for the legendary life of a villain, left him and sought another job. One day, Gru was kidnapped by Lucy Wilde (Kristen Wiig), a skilled but reckless agent. It turned out that Lucy's group had developed drugs that could change biological genes, but their laboratory in Antarctica was stolen by a mysterious thief, so Gru, who had experience as a villain, was commissioned to go undercover. After some consideration, Gru accepted the mission and formed a hilarious murder-chasing partnership with Lucy, along with the super cute Minions...