Maggie (Kristen Wiig) and Milo (Bill Hader) are twins, but they are very distant from each other. They haven't even seen each other or talked for many years. Being in a different place, the life of the two siblings is also not happy. Maggie thought her marriage was a model, but she didn't know when she and her husband had already become strangers. Milo has been unable to get out of the shadow after losing his love, nor can he start another relationship. One day, as if they had a telepathic connection, Maggie and Milo chose to commit suicide at the same time. Fortunately, both of them survived. This special experience brought the two siblings back together. They returned to the small town where they grew up in their childhood, where they were waiting for memories and a new direction for their future life.