"Caregiver's Story" tells the story of a retired writer (played by Paul Rudd) who becomes a carer after experiencing his own life tragedy. After six weeks of training, he meets his first client, an 18-year-old foul-mouthed muscular dystrophy youth (played by Craig Roberts). The "paralyzed" emotions and paralyzed bodies meet unexpectedly, and the two embark on a road trip. Along the way, they meet a talkative lost girl, a pregnant woman who helps them test their personal survival skills, and so on. After a series of stories, they understand the importance of keeping hope when life is frustrated, and also gain true friendship.