The final episode of "Jin Yi 2" continues the plot of the previous episode. History is still moving forward in an orderly manner in the established direction, and more familiar historical characters appear. Minami Jin (played by Takao Ozawa) survived in the Edo period as a doctor, and the clinic Jinyoutang he opened was also on track. One day he learned that Tachibana Saki's (Ayase Haruka) mother suffered from beriberi, which was common at the time, and decided to make and popularize snacks that could cure the disease. At the same time, Sakamoto Ryoma (Uchino Seiyo) appeared in front of Jin and asked for help. Jin followed Ryoma to Kyoto to treat Katsu Kaishu's master Sakuma Shouzan, and learned about the amazing past from the latter who woke up... After the Kinmon Incident, Kyoto was devastated, and Jin, who had stayed to save people, was taken to Satsuma by the Shinsengumi to treat Saigo Takamori. After that, Sakamoto Ryoma brought Saigo Takamori and Choshu together to promote the Satsuma-Choshu alliance. Witnessing the sudden changes in the situation in Japan at the end of the shogunate, Jin has a new understanding of his significance in this era. In the near future, he will meet Nokaze (Miki Nakatani) again who is looking for a new life, and the mysteries surrounding them in the previous part will be solved one by one.