At a museum reception in Washington, D.C., an ancient head sculpture summoned an evil force. A museum staff member rushed towards the US President who had just come in to visit with a sharp weapon. Secret Service agents Myka (Joanne Kelly) and Pete (Eddie McClintock) were fearless and protected the president to solve the crisis of the stone statue. The two received a commission from Mrs. Frederic (C.H. Pounder) that night, and as partners, they went to a barren land in South Dakota to perform the mission. The deadline for the mission was - no time limit. This top-secret location was called Warehouse 13. This place was originally a huge warehouse, and the things stored in the warehouse were some very strange "artworks". These artworks were collected from all over the place, and the new job of these two agents was to find art collections with "unknown abilities".