On the beautiful, romantic and warm Caribbean coast, the young man Marcus (Mitch Ryan) and his beautiful bride Kate (Claudette Lali) held a grand wedding. During the wedding, Marcus took his younger brother Josh (Brando Eaton), the beautiful girl Penny (Jillian Murray), his good friend Dobbs (Ryan Donowho) and others to sail on a yacht for fun. They came to an uninhabited desert island for adventure, enjoying the fun, but they didn't know that the footsteps of death were approaching little by little. Not long ago, the mysterious and terrifying virus spread wantonly on the island, causing huge casualties. As the only survivor, Porter (Sean Astin) hated his son's death, so he not only refused to cooperate with relevant researchers, but also maliciously spread the virus in his body. Marcus and others who accidentally stepped into this dead land discovered the secrets hidden on the island, and at the same time ushered in the most terrifying moment in their lives...