This story takes place in the late Qing Dynasty. In order to save the life of his beloved daughter (Zhu Yana), Prince Jing (Xu Liansheng) had to seek medical help from all directions and found Xilaile (Li Baotian), a country doctor from Cangzhou. Unexpectedly, Xilaile, who was diagnosed as terminally ill by the imperial physician Wang Tianhe (Du Yulu), used a strange trick to save the princess. Xilaile was originally a person who did not fight with the world and did not want to stay in the capital, a place of right and wrong. However, God made people play tricks on him. Prince Jing not only used a trick to keep him, but also moved his whole family and Cangzhou's "Yixiaotang" to the capital. From then on, the arrogant doctor Wang Taiyi had a grudge with Xilaile and repeatedly poisoned Xilaile. The lucky Xilaile not only avoided the plot every time, but also won the title of a miracle doctor in the capital with his own strange prescriptions. In order to let Xilaile stay in the capital with peace of mind, Prince Jing even moved his old lover, the widow Sai Xishi (played by Shen Aojun) in Cangzhou and her shop "Food is Heaven" to the opposite of "Yixiaotang". Xilaile's jealous wife Hu (played by Liang Li) is a tigress who is not easy to mess with. The arrival of Sai Xishi makes their family restless every day. Xilaile's fame is getting bigger and bigger, and he is even appreciated by the emperor and Cixi. Doctor Wang also stepped up his steps to frame him. What is waiting for Xilaile's family?