In Brewster, southern Pennsylvania, veteran train pilot Frank Barnes (Denzel Washington) is about to retire early. As an old employee with rich experience and experience, he and his partners are dissatisfied with the company's relatively cheap but inexperienced new employees for cost, but they can do nothing about it. This morning, Frank ushered in a new partner, the young and vigorous navigator Will Colson (Chris Pine), and the old and new alternation officially began. At the same time, the Fuller Station in the north had a problem. The 777 train loaded with dangerous chemicals drove away without a driver, roaring like a beast and rushing towards the densely populated town. Danger is coming at any time, and Frank and Will are about to spend an unforgettable day... This film is adapted from a real event in Ohio, USA in 2001.