This film is a remake of the 2005 Danish film of the same name. In order to save his wife, Will Sharp (Yahya Abdul-Mateen II), a meritorious veteran, finds his adoptive brother Danny (Jake Gyllenhaal) for help, but is involved in the largest bank robbery in Los Angeles history. A fatal mistake during the escape forces the two to hijack an ambulance carrying a dying police officer and a top emergency expert Cam Thompson (Eiza Gonzalez). In this long-lasting high-speed chase, Will and Danny try their best to avoid a large-scale manhunt by the police throughout the city, ensure the safety of the hostages, and try not to draw knives against their brothers, while completing the most crazy and thrilling escape in Los Angeles history.