It is said that the story takes place in the Ming Dynasty 500 years ago. The capital is majestic, crowded with people, shoulder to shoulder, a scene of prosperity. In a corner of the capital, there is a Tianhe Medical Clinic. The owner Chen Muchan (played by Yang Haoyu) is famous in the capital for treating difficult and complicated diseases, but he has an unknown identity, that is, a spy from the West Factory. One day, Chen Muchan suddenly disappeared, and Zhu Yipin (played by Chen He), an apprentice who volunteered to become an imperial physician, got a scroll of great importance. Family changes made Miss Chen Anan (played by Zhang Zixuan) very sad, and the appearance of the scroll involved Yipin, his fellow apprentice Zhao Buzhu (played by Tong Lei), and Chen Anan in an unprecedented storm. Yang Yuxuan (played by Wang Chuanjun) and Liu Ruoxin (played by Jiang Yan), two masters from the East Factory and the West Factory respectively, sneaked into the Tianhe Medical Clinic one after another. While fighting against each other and deceiving each other, they also derived a series of love stories that were not cleaned up...