Adam (Tom Hiddleston) and Eve (Tilda Swinton) are a pair of vampire lovers who have traveled through hundreds of years together, from the Middle Ages to the modern times. They have experienced several ups and downs in human society and are currently separated in Detroit and Tangier. Adam is an underground musician who hates incompetent and cruel humans and calls them "zombies". Adam, who is unable to extricate himself from depression, even buys wooden bullets and thinks of committing suicide. Eve travels a long way to Adam's side after learning of her lover's poor condition. The brief reunion brings new hope to Adam, but what makes him unhappy is that Eve's notorious sister Ava (Mia Wasikowska) also breaks into their lives. Ava's arrival brought disaster and curse. Not only did she kill Adam's only human friend, Ilan (Anton Yelchin), but she also messed up the lives of her sister and brother-in-law.