The play describes the work and life story of a female secretary of state - she must find a balance between international crises, office politics and complex family life. It is said that the prototype of this female secretary of state is Hillary Clinton, but CBS refuses to admit it. Elizabeth McCord (Tea Leoni), who is shrewd, determined and intelligent, has just been appointed as the US Secretary of State. She will find a balance between international diplomatic affairs, office politics and various "circumvention procedures". While solving national affairs, she also faces many personal troubles - both from the White House and from home. Elizabeth used to be a university professor and later worked as a CIA analyst, but resigned for moral and ethical reasons. The former Secretary of State died mysteriously, and the president ordered her to return to the White House, so she returned to the public eye. The president respects her attitude of not having obvious political inclinations, and appreciates her thorough understanding of Middle Eastern affairs, her ability to speak multiple languages fluently and her creative thinking. In fact... nothing has ever constrained her thinking. McCord's team includes her chief of staff, Nadine Tolliver (Emmy Award winner Bebe Neuwirth), speechwriter Matt Mahoney (Geoffrey Arend), media liaison officer Daisy Grant (Patina Miller) and charming assistant Blake Moran (Erich Bergen). Moran is extremely loyal to Elizabeth. In fact, he is the only one in Elizabeth's team hired by Elizabeth herself. After arguing about the issues of third world countries and skillfully handling relations with foreign dignitaries, she dragged her tired body back to her warm home, where her husband Henry (Tim Daly) who has always supported her silently and two smart children (Katherine Herzer and Evan Roe) are waiting for her to have dinner together. For her, "politics" and "crisis" have completely different meanings at home. Henry is a professor of medieval religious history who is so obsessed with his work that he can talk about the theory of "Thomas Aquinas" for two hours in a row without repeating a word. The son Adam is in adolescence and is a budding anarchist. The daughter Caroline is as beautiful and outgoing as her mother and is popular wherever she goes.