Alice (Julianne Moore) is a successful university professor of linguistics. She has been married to her husband John (Alec Baldwin) for many years and has a very good relationship. They have three children, Lydia (Kristen Stewart), Pheglia (Kate Bosworth) and Tom (Hunter Parrish), and each child has grown up healthily. At the age of fifty, Alice suffered the biggest change in her life. At first, she just found that her memory had deteriorated a little. As time went on, this deterioration became more and more serious. After the doctor's diagnosis, she suffered from Alzheimer's disease. With abundant emotions, precious memories, and wise thoughts, Alice gradually lost everything important in her life. However, with the company and encouragement of her family, she did not lose the hope of living, and bravely and strongly greeted the new day.