The heroine Anna (Milla Jovovich) accidentally witnessed a murder on the street. She was discovered and chased by the gangsters. In the panic, Anna was injured and fell into the river but survived. Anna became the only eyewitness who survived and saw the true face of the murderer. The police decided to find a breakthrough in solving the serial murder case from Anna. The injured Anna woke up from a coma a week later, but found that every face she saw was constantly changing and deforming-she could no longer recognize the faces of people around her, including her boyfriend and father. This symptom is medically called "prosopagnosia", also known as "face blindness". The murderer seemed to know the secret that Anna suffered from face blindness due to brain injury. In order to test whether Anna really could not recognize herself, the murderer constantly tested and provoked Anna through various means. Anna felt that the murderer was following her like a shadow, threatening her life at any time. Finally, the murderer confirmed that Anna could only identify different people by the color of clothes and the style of ties, so he decided to take a risk and put on Anna's ex-boyfriend's clothes and tie to meet Anna, ready to take Anna to a remote place and kill her. However, a mistake in a detail made Anna suddenly realize that the man in front of her was not her ex-boyfriend, but the criminal who wanted to kill her. After receiving Anna's call, the police rushed to rescue Anna, and a life-and-death battle broke out, and finally arrested the murderer.