In Prague, Czech Republic, professional killer Joe (Nicolas Cage) completed a mission with a sophisticated method. For a long time, the four principles that Joe believed in made him ruthlessly complete missions and live out of everyone's sight, but this kind of wandering and lonely life made people tired, so Joe decided to go to Bangkok to complete the last four missions. Joe found a local pickpocket Kang in the brightly lit streets of Bangkok to serve as his assistant and translator, responsible for connecting with the Thai employer. Joe quickly completed the first mission, paying the price of a scratch on his right arm. Joe, who went to the pharmacy for help, met the deaf-mute girl Fon (played by Charlie Young), whose gentle attitude made Joe feel concerned... Kang was beaten by a group of gangsters on the way to the connection. Kang, who was covered with scars, moved Joe. Joe taught him fighting skills, and his cold principles began to waver. Joe's last mission was to assassinate a daring and upright politician. Kang's words were still in his ears, which made him hesitate to act. On the other hand, the Thai employer was afraid that the matter would be exposed and wanted to kill him to silence him. Joe's battle with his gangster employer is inevitable...