In the 19th century, there was a mysterious area in Romania where humans and ghosts coexisted - the ancient town of Transinia. There was an evil force in the town that ruled the area after dark, that is, the demons and monsters led by the vampire Dracula (Richard Roxburgh). They came out to kill as soon as it got dark, and their methods were extremely cruel. What's more terrifying is that this team is growing, and the bloodthirsty Frankenstein has also come from afar to join Dracula. After many failed expeditions, the Catholic Church in Romania went to the United States to invite the vampire hunter Van Helsing (Hugh Jackman). On the way to Transinia with his assistant, Van Helsing saved another vampire hunter - Anna (Kate Beckinsale) by coincidence. Anna's family was destroyed because of the curse of Dracula for generations, and she has trained a set of ghost hunting skills since she was a child. Anna and Van Helsing hit it off and went to deal with Dracula together...